{"product_id":"mots-c-10mg","title":"MOTS-c 10mg","description":"\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBatch HPLC tested at 98.5%+ purity\u003c\/li\u003e\n\u003cli\u003eStore frozen long term or in fridge when ready to be used\u003c\/li\u003e\n\u003cli\u003eSold for research purposes only\u003c\/li\u003e\n\u003cli\u003eContact us for Wholesale Orders\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDownload COA here: \u003ca href=\"https:\/\/zenovussciences.com\/wp-content\/uploads\/2026\/06\/OP_MOTS-c_COA_sample.pdf\" rel=\"noopener\" target=\"_blank\"\u003eMOTS-C_COA.pdf\u003c\/a\u003e\u003c\/strong\u003e\u003cbr\u003ePlease note: if you have a different Batch ID please contact us for the latest COA.\u003c\/p\u003e\n\u003ch3\u003eMOTS-c\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSynonyms \/ Designations: \u003c\/strong\u003eMOTS-c, Mitochondrial ORF of the Twelve S rRNA-c\u003cbr\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1627580-64-6\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C101H152N28O22S2\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e ~2174.64 g\/mol\u003cbr\u003e\u003cstrong\u003ePeptide Length:\u003c\/strong\u003e 16 amino acids\u003cbr\u003e\u003cstrong\u003ePeptide Type:\u003c\/strong\u003e Mitochondrial-derived regulatory peptide\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99 % (HPLC, typical)\u003cbr\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e White to off-white lyophilised powder\u003cbr\u003e\u003cstrong\u003ePack Size:\u003c\/strong\u003e 10 mg (typical)\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Desiccated, protected from light, stored at –20 °C or below\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in water and buffered aqueous solutions\u003c\/p\u003e\n\u003ch3\u003eDescription \u0026amp; Mechanism\u003c\/h3\u003e\n\u003cp\u003eMOTS-c is a synthetic peptide corresponding to a naturally occurring mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It is used in experimental research to investigate mitochondrial signalling, metabolic regulation, and nuclear–mitochondrial communication pathways.\u003c\/p\u003e\n\u003cp\u003eIn biochemical and cellular research systems, MOTS-c has been shown to influence intracellular signalling pathways associated with energy sensing, insulin signalling, and cellular stress responses. Experimental models examine its effects on AMPK activation, metabolic gene expression, and adaptive stress signalling. Observed molecular responses depend on concentration, exposure duration, and experimental model.\u003c\/p\u003e\n\u003ch3\u003eApplications in Research\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAs a molecular probe for studying mitochondrial-derived peptide signalling.\u003c\/li\u003e\n\u003cli\u003eInvestigation of metabolic regulation and energy homeostasis pathways.\u003c\/li\u003e\n\u003cli\u003eIn vitro studies examining mitochondrial–nuclear communication.\u003c\/li\u003e\n\u003cli\u003eUse as a reference compound in metabolism and mitochondrial biology research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications Summary\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e (HPLC): ≥ 99 %\u003cbr\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e White to off-white lyophilised powder\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e ~2174.64 g\/mol\u003cbr\u003e\u003cstrong\u003ePeptide Type:\u003c\/strong\u003e Mitochondrial-derived peptide\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water, buffered aqueous solutions\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e –20 °C, desiccated, protected from light\u003cbr\u003e\u003cstrong\u003ePack Size:\u003c\/strong\u003e 10 mg\u003c\/p\u003e\n\u003ch3\u003eHandling, Reconstitution \u0026amp; Stability\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eWeigh under dry conditions; peptide is hygroscopic.\u003c\/li\u003e\n\u003cli\u003eReconstitute in sterile water or appropriate buffered aqueous solution.\u003c\/li\u003e\n\u003cli\u003eAvoid vigorous agitation during dissolution.\u003c\/li\u003e\n\u003cli\u003eFilter sterilize if required prior to use.\u003c\/li\u003e\n\u003cli\u003eAliquot and store reconstituted solutions at –20 °C or lower.\u003c\/li\u003e\n\u003cli\u003eAvoid repeated freeze–thaw cycles.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003ePrecautions \u0026amp; Notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eExperimental behaviour of MOTS-c is influenced by metabolic state, cell type, and peptide concentration.\u003c\/li\u003e\n\u003cli\u003eBuffer composition, pH, and ionic strength may affect peptide stability.\u003c\/li\u003e\n\u003cli\u003eAppropriate controls are recommended.\u003c\/li\u003e\n\u003cli\u003eIntended strictly for laboratory research use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eLee C. et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 2015.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25738459\/\" rel=\"noopener\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/25738459\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eReynolds J.C. et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 2021.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33446706\/\" rel=\"noopener\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/33446706\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKim K.H. et al. Mitochondrial-derived peptides as novel regulators of metabolism. Journal of Physiology, 2017.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28488752\/\" rel=\"noopener\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/28488752\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKeywords:\u003c\/strong\u003e MOTS-c, Mitochondrial Peptide, Metabolic Regulation, AMPK Signalling, Synthetic Peptide\u003c\/p\u003e","brand":"Zenovus Sciences","offers":[{"title":"Default Title","offer_id":54752965198165,"sku":null,"price":29.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1074\/1661\/7301\/files\/MOTS-c10mg.png?v=1787734670","url":"https:\/\/zenovussciences.com\/products\/mots-c-10mg","provider":"Zenovus Sciences","version":"1.0","type":"link"}